Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

Mutations in isocitrate dehydrogenase (IDH) genes occur in multiple cancer types, lead to global changes in the epigenome, and drive tumorigenesis. Yet, effective strategies targeting solid tumors harboring IDH mutations remain elusive. Here, we demonstrate that IDH-mutant gliomas and cholangiocarci...

詳細記述

保存先:
書誌詳細
出版年:Sci Adv
主要な著者: Wang, Yuxiang, Wild, Aaron T., Turcan, Sevin, Wu, Wei H., Sigel, Carlie, Klimstra, David S., Ma, Xiaoxiao, Gong, Yongxing, Holland, Eric C., Huse, Jason T., Chan, Timothy A.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2020
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176409/
https://ncbi.nlm.nih.gov/pubmed/32494639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz3221
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