Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

Mutations in isocitrate dehydrogenase (IDH) genes occur in multiple cancer types, lead to global changes in the epigenome, and drive tumorigenesis. Yet, effective strategies targeting solid tumors harboring IDH mutations remain elusive. Here, we demonstrate that IDH-mutant gliomas and cholangiocarci...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Wang, Yuxiang, Wild, Aaron T., Turcan, Sevin, Wu, Wei H., Sigel, Carlie, Klimstra, David S., Ma, Xiaoxiao, Gong, Yongxing, Holland, Eric C., Huse, Jason T., Chan, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176409/
https://ncbi.nlm.nih.gov/pubmed/32494639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz3221
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker