Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

Mutations in isocitrate dehydrogenase (IDH) genes occur in multiple cancer types, lead to global changes in the epigenome, and drive tumorigenesis. Yet, effective strategies targeting solid tumors harboring IDH mutations remain elusive. Here, we demonstrate that IDH-mutant gliomas and cholangiocarci...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Wang, Yuxiang, Wild, Aaron T., Turcan, Sevin, Wu, Wei H., Sigel, Carlie, Klimstra, David S., Ma, Xiaoxiao, Gong, Yongxing, Holland, Eric C., Huse, Jason T., Chan, Timothy A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2020
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176409/
https://ncbi.nlm.nih.gov/pubmed/32494639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz3221
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