Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

The development of novel analgesics with improved safety profiles to combat the opioid epidemic represents a central question to G protein coupled receptor structural biology and pharmacology: What chemical features dictate G protein or β-arrestin signaling? Here we use adaptively biased molecular d...

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Udgivet i:PLoS Comput Biol
Main Authors: de Waal, Parker W., Shi, Jingjing, You, Erli, Wang, Xiaoxi, Melcher, Karsten, Jiang, Yi, Xu, H. Eric, Dickson, Bradley M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176292/
https://ncbi.nlm.nih.gov/pubmed/32275713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007394
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