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Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing
5-hydroxymethylcytosine (5hmC) is the most prevalent intermediate on the oxidative DNA demethylation pathway and is implicated in regulation of embryogenesis, neurological processes, and cancerogenesis. Profiling of this relatively scarce genomic modification in clinical samples requires cost-effect...
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| Veröffentlicht in: | PLoS Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7176277/ https://ncbi.nlm.nih.gov/pubmed/32275660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000684 |
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