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Methyltransferase-directed derivatization of 5-hydroxymethylcytosine in DNA
[Image: see text] Cytosine modification by AdoMet–dependent DNA methyltransferases is part of an epigenetic regulatory network in vertebrates. Here we show that, in the absence of AdoMet, bacterial cytosine-5 methyltransferases can catalyze condensation of aliphatic thiols and selenols to 5-hydroxym...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137911/ https://ncbi.nlm.nih.gov/pubmed/21344558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201007169 |
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