Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation

The lysosome is an acidic multi-functional organelle with roles in macromolecular digestion, nutrient sensing and signaling. However, why cells require acidic lysosomes to proliferate and which nutrients become limiting under lysosomal dysfunction are unclear. To address this, we performed CRISPR/Ca...

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Pubblicato in:Mol Cell
Autori principali: Weber, Ross A., Yen, Frederick S., Nicholson, Shirony P.V., Alwaseem, Hanan, Bayraktar, Erol C., Alam, Mohammad, Timson, Rebecca C., La, Konnor, Abu-Remaileh, Monther, Molina, Henrik, Birsoy, Kıvanç
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176020/
https://ncbi.nlm.nih.gov/pubmed/31983508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.003
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