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VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle
Differentiated tissue is particularly vulnerable to alterations in protein and organelle homeostasis. The essential protein VCP, mutated in hereditary inclusion body myopathy, amyotrophic lateral sclerosis and frontotemporal dementia, is critical for efficient clearance of misfolded proteins and dam...
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| Publicado no: | Autophagy |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6526815/ https://ncbi.nlm.nih.gov/pubmed/30654731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1569933 |
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