VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle

Differentiated tissue is particularly vulnerable to alterations in protein and organelle homeostasis. The essential protein VCP, mutated in hereditary inclusion body myopathy, amyotrophic lateral sclerosis and frontotemporal dementia, is critical for efficient clearance of misfolded proteins and dam...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Arhzaouy, Khalid, Papadopoulos, Chrisovalantis, Schulze, Nina, Pittman, Sara K., Meyer, Hemmo, Weihl, Conrad C.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526815/
https://ncbi.nlm.nih.gov/pubmed/30654731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1569933
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