Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation

The lysosome is an acidic multi-functional organelle with roles in macromolecular digestion, nutrient sensing and signaling. However, why cells require acidic lysosomes to proliferate and which nutrients become limiting under lysosomal dysfunction are unclear. To address this, we performed CRISPR/Ca...

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Udgivet i:Mol Cell
Main Authors: Weber, Ross A., Yen, Frederick S., Nicholson, Shirony P.V., Alwaseem, Hanan, Bayraktar, Erol C., Alam, Mohammad, Timson, Rebecca C., La, Konnor, Abu-Remaileh, Monther, Molina, Henrik, Birsoy, Kıvanç
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176020/
https://ncbi.nlm.nih.gov/pubmed/31983508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.003
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