Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Adv Sci (Weinh)
Päätekijät: Liu, Xinxin, Zhang, Xiaoli, Peng, Zhiqiang, Li, Chunnan, Wang, Ze, Wang, Chanjuan, Deng, Zhikang, Wu, Bo, Cui, Yu, Wang, Zhanxin, Cui, Chun‐Ping, Zheng, Min, Zhang, Lingqiang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Full Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://ncbi.nlm.nih.gov/pubmed/32328410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902040
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