The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras(G12D)-dr...

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Publicado en:Nat Commun
Main Authors: Du, Tongde, Li, Hongchang, Fan, Yongsheng, Yuan, Lin, Guo, Xiaodan, Zhu, Qiong, Yao, Yuying, Li, Xin, Liu, Chunlei, Yu, Xinhe, Liu, Zhaofei, Cui, Chun-Ping, Han, Chuanchun, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606649/
https://ncbi.nlm.nih.gov/pubmed/31266968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10824-7
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