The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras(G12D)-dr...

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Udgivet i:Nat Commun
Main Authors: Du, Tongde, Li, Hongchang, Fan, Yongsheng, Yuan, Lin, Guo, Xiaodan, Zhu, Qiong, Yao, Yuying, Li, Xin, Liu, Chunlei, Yu, Xinhe, Liu, Zhaofei, Cui, Chun-Ping, Han, Chuanchun, Zhang, Lingqiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606649/
https://ncbi.nlm.nih.gov/pubmed/31266968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10824-7
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