Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular...

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Bibliografske podrobnosti
izdano v:Adv Sci (Weinh)
Main Authors: Liu, Xinxin, Zhang, Xiaoli, Peng, Zhiqiang, Li, Chunnan, Wang, Ze, Wang, Chanjuan, Deng, Zhikang, Wu, Bo, Cui, Yu, Wang, Zhanxin, Cui, Chun‐Ping, Zheng, Min, Zhang, Lingqiang
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Full Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://ncbi.nlm.nih.gov/pubmed/32328410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902040
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