USP9X destabilizes pVHL and promotes cell proliferation

Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Zhang, Cong, Peng, Zuohan, Zhu, Minglu, Wang, Penglong, Du, Xiao, Li, Xiang, Liu, Yu, Jin, Yan, McNutt, Michael A., Yin, Yuxin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312400/
https://ncbi.nlm.nih.gov/pubmed/27517496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11139
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