WSB1 promotes tumor metastasis by inducing pVHL degradation

The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is known with regard...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Kim, Jung Jin, Lee, Seung Baek, Jang, Jinsung, Yi, Sang-Yeop, Kim, Sun-Hyun, Han, Sang-Ah, Lee, Jong-Min, Tong, Seo-Yun, Vincelette, Nicole D., Gao, Bowen, Yin, Ping, Evans, Debra, Choi, Dong Wook, Qin, Bo, Liu, Tongzheng, Zhang, Haoxing, Deng, Min, Jen, Jin, Zhang, Jun, Wang, Liewei, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647558/
https://ncbi.nlm.nih.gov/pubmed/26545811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268128.115
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