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WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation
Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell proliferation, genomic instability, and cellular transformation, and finally allows cancers to develop. However, it remains unclear...
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| Publicado no: | Cell Res |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339850/ https://ncbi.nlm.nih.gov/pubmed/27958289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.148 |
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