WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell proliferation, genomic instability, and cellular transformation, and finally allows cancers to develop. However, it remains unclear...

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Bibliografische gegevens
Gepubliceerd in:Cell Res
Hoofdauteurs: Kim, Jung Jin, Lee, Seung Baek, Yi, Sang-Yeop, Han, Sang-Ah, Kim, Sun-Hyun, Lee, Jong-Min, Tong, Seo-Yun, Yin, Ping, Gao, Bowen, Zhang, Jun, Lou, Zhenkun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339850/
https://ncbi.nlm.nih.gov/pubmed/27958289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.148
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