WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell proliferation, genomic instability, and cellular transformation, and finally allows cancers to develop. However, it remains unclear...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Res
Hauptverfasser: Kim, Jung Jin, Lee, Seung Baek, Yi, Sang-Yeop, Han, Sang-Ah, Kim, Sun-Hyun, Lee, Jong-Min, Tong, Seo-Yun, Yin, Ping, Gao, Bowen, Zhang, Jun, Lou, Zhenkun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339850/
https://ncbi.nlm.nih.gov/pubmed/27958289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.148
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