USP9X destabilizes pVHL and promotes cell proliferation

Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhang, Cong, Peng, Zuohan, Zhu, Minglu, Wang, Penglong, Du, Xiao, Li, Xiang, Liu, Yu, Jin, Yan, McNutt, Michael A., Yin, Yuxin
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312400/
https://ncbi.nlm.nih.gov/pubmed/27517496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11139
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