Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Liu, Xinxin, Zhang, Xiaoli, Peng, Zhiqiang, Li, Chunnan, Wang, Ze, Wang, Chanjuan, Deng, Zhikang, Wu, Bo, Cui, Yu, Wang, Zhanxin, Cui, Chun‐Ping, Zheng, Min, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://ncbi.nlm.nih.gov/pubmed/32328410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902040
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