Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular...

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Veröffentlicht in:Adv Sci (Weinh)
Hauptverfasser: Liu, Xinxin, Zhang, Xiaoli, Peng, Zhiqiang, Li, Chunnan, Wang, Ze, Wang, Chanjuan, Deng, Zhikang, Wu, Bo, Cui, Yu, Wang, Zhanxin, Cui, Chun‐Ping, Zheng, Min, Zhang, Lingqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://ncbi.nlm.nih.gov/pubmed/32328410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201902040
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