Role of p53 in the Regulation of Cellular Senescence

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle a...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Mijit, Mahmut, Caracciolo, Valentina, Melillo, Antonio, Amicarelli, Fernanda, Giordano, Antonio
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175209/
https://ncbi.nlm.nih.gov/pubmed/32182711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10030420
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