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Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms

Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP or through cellular reprogramming represents a novel therapeutic avenue for treating cancer- and age-related diseases such as ne...

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Vydáno v:Carcinogenesis
Hlavní autoři: Beck, Jessica, Turnquist, Casmir, Horikawa, Izumi, Harris, Curtis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422622/
https://ncbi.nlm.nih.gov/pubmed/32619002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa071
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