p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression. Here, we found that the endogenous p53 isoforms Δ133p53 and p53β are physiological regulators of prolifera...

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Detalhes bibliográficos
Main Authors: Mondal, Abdul M., Horikawa, Izumi, Pine, Sharon R., Fujita, Kaori, Morgan, Katherine M., Vera, Elsa, Mazur, Sharlyn J., Appella, Ettore, Vojtesek, Borivoj, Blasco, Maria A., Lane, David P., Harris, Curtis C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859419/
https://ncbi.nlm.nih.gov/pubmed/24231352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70355
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