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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression. Here, we found that the endogenous p53 isoforms Δ133p53 and p53β are physiological regulators of prolifera...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859419/ https://ncbi.nlm.nih.gov/pubmed/24231352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70355 |
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