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Reversal of human cellular senescence: roles of the p53 and p16 pathways
Telomere erosion and subsequent dysfunction limits the proliferation of normal human cells by a process termed replicative senescence. Replicative senescence is thought to suppress tumorigenesis by establishing an essentially irreversible growth arrest that requires activities of the p53 and pRB tum...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC175806/ https://ncbi.nlm.nih.gov/pubmed/12912919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg417 |
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