Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition

Human immunodeficiency virus type 1 (HIV-1) replication in T cells can be inhibited by RNA interference (RNAi) through short hairpin RNA (shRNA) expression from a lentiviral vector. However, for the development of a durable RNAi-based gene therapy against HIV-1, multiple shRNAs need to be expressed...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Brake, Olivier ter, Hooft, Karen 't, Liu, Ying Poi, Centlivre, Mireille, Jasmijn von Eije, Karin, Berkhout, Ben
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Gene Therapy. Published by Elsevier Inc. 2008
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7172400/
https://ncbi.nlm.nih.gov/pubmed/18180777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300382
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