Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies

RNAi-based gene therapy is a powerful approach to treat viral infections because of its high efficiency and sequence specificity. The HIV-1-based lentiviral vector system is suitable for the delivery of RNAi inducers to HIV-1 susceptible cells due to its ability to transduce nondividing cells, inclu...

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Main Authors: Liu, Ying Poi, Vink, Monique A., Westerink, Jan-Tinus, Ramirez de Arellano, Eva, Konstantinova, Pavlina, Ter Brake, Olivier, Berkhout, Ben
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885682/
https://ncbi.nlm.nih.gov/pubmed/20498457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1887910
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