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Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs
BACKGROUND: RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism that mediates the sequence-specific breakdown of target mRNAs. RNAi can be used to inhibit HIV-1 replication by targeting the viral RNA genome. However, the error-prone replication machinery of HIV-1 can genera...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898777/ https://ncbi.nlm.nih.gov/pubmed/20529316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-52 |
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