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A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs

RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism in which small interfering RNA (siRNA) mediates the sequence specific degradation of mRNA. The recent discovery that exogenously delivered siRNA can trigger RNAi in mammalian cells raises the possibility to use this techno...

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Detalhes bibliográficos
Main Authors: ter Brake, Olivier, Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Library Publishing Media 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737200/
https://ncbi.nlm.nih.gov/pubmed/19771206
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