Загрузка...
DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs
RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNA(miR)) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNA(miR)-containing recombinant vectors and hypothesized that this could be due to cleavage of viral genomic RNA by the en...
Сохранить в:
| Опубликовано в: : | Mol Ther Nucleic Acids |
|---|---|
| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Gene & Cell Therapy
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078836/ https://ncbi.nlm.nih.gov/pubmed/30195795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.07.002 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|