DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs

RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNA(miR)) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNA(miR)-containing recombinant vectors and hypothesized that this could be due to cleavage of viral genomic RNA by the en...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Park, Hee Ho, Triboulet, Robinson, Bentler, Martin, Guda, Swaroopa, Du, Peng, Xu, Haiming, Gregory, Richard I., Brendel, Christian, Williams, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078836/
https://ncbi.nlm.nih.gov/pubmed/30195795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.07.002
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