miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction

RNA interference (RNAi) technology using short hairpin RNAs (shRNAs) expressed via RNA polymerase (pol) III promoters has been widely exploited to modulate gene expression in a variety of mammalian cell types. For certain applications, such as lineage-specific knockdown, embedding targeting sequence...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Guda, Swaroopa, Brendel, Christian, Renella, Raffaele, Du, Peng, Bauer, Daniel E, Canver, Matthew C, Grenier, Jennifer K, Grimson, Andrew W, Kamran, Sophia C, Thornton, James, de Boer, Helen, Root, David E, Milsom, Michael D, Orkin, Stuart H, Gregory, Richard I, Williams, David A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817887/
https://ncbi.nlm.nih.gov/pubmed/26080908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.113
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