Potent USP10/13 antagonist spautin‐1 suppresses melanoma growth via ROS‐mediated DNA damage and exhibits synergy with cisplatin

Malignant melanoma is one of the most invasive tumours. However, effective therapeutic strategies are limited, and overall survival rates remain low. By utilizing transcriptomic profiling, tissue array and molecular biology, we revealed that two key ubiquitin‐specific proteases (USPs), ubiquitin‐spe...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Cell Mol Med
Auteurs principaux: Guo, Jia, Zhang, JiangLing, Liang, Long, Liu, Nian, Qi, Min, Zhao, Shuang, Su, Juan, Liu, Jing, Peng, Cong, Chen, Xiang, Liu, Hong
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171391/
https://ncbi.nlm.nih.gov/pubmed/32129945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15093
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