Potent USP10/13 antagonist spautin‐1 suppresses melanoma growth via ROS‐mediated DNA damage and exhibits synergy with cisplatin

Malignant melanoma is one of the most invasive tumours. However, effective therapeutic strategies are limited, and overall survival rates remain low. By utilizing transcriptomic profiling, tissue array and molecular biology, we revealed that two key ubiquitin‐specific proteases (USPs), ubiquitin‐spe...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Guo, Jia, Zhang, JiangLing, Liang, Long, Liu, Nian, Qi, Min, Zhao, Shuang, Su, Juan, Liu, Jing, Peng, Cong, Chen, Xiang, Liu, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171391/
https://ncbi.nlm.nih.gov/pubmed/32129945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15093
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