Tirapazamine-cisplatin: the synergy.

Tirapazamine is a novel bioreductive agent with selective cytotoxicity against hypoxic tumour cells. Synergy with cisplatin and other chemotherapeutic agents has been shown in preclinical trials. Pharmacokinetic studies of tirapazamine have revealed that exposure increases with dose over the range o...

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Autori principali: Gatzemeier, U., Rodriguez, G., Treat, J., Miller, V., von Roemeling, R., Viallet, J., Rey, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149886/
https://ncbi.nlm.nih.gov/pubmed/9647615
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