Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting Mpc1, an obligate M...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Ramstead, Andrew G., Wallace, Jared A., Lee, Soh-Hyun, Bauer, Kaylyn M., Tang, William W., Ekiz, H. Atakan, Lane, Thomas E., Cluntun, Ahmad A., Bettini, Matthew L., Round, June L., Rutter, Jared, O’Connell, Ryan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170217/
https://ncbi.nlm.nih.gov/pubmed/32130894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.042
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