Hepatic Mitochondrial Pyruvate Carrier 1 is Required for Efficient Regulation of Gluconeogenesis and Whole-body Glucose Homeostasis

Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during Type 2 Diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mitochondrial matrix for channeling into gluconeogenesis. Her...

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Vydáno v:Cell Metab
Hlavní autoři: Gray, Lawrence R., Sultana, Mst Rasheda, Rauckhorst, Adam J., Oonthonpan, Lalita, Tompkins, Sean C., Sharma, Arpit, Fu, Xiaorong, Miao, Ren, Pewa, Alvin D., Brown, Kathryn S., Lane, Erin E., Dohlman, Ashley, Zepeda-Orozco, Diana, Xie, Jianxin, Rutter, Jared, Norris, Andrew W., Cox, James E., Burgess, Shawn C., Potthoff, Matthew J., Taylor, Eric B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754674/
https://ncbi.nlm.nih.gov/pubmed/26344103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.07.027
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