Hepatic Mitochondrial Pyruvate Carrier 1 is Required for Efficient Regulation of Gluconeogenesis and Whole-body Glucose Homeostasis

Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during Type 2 Diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mitochondrial matrix for channeling into gluconeogenesis. Her...

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Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Gray, Lawrence R., Sultana, Mst Rasheda, Rauckhorst, Adam J., Oonthonpan, Lalita, Tompkins, Sean C., Sharma, Arpit, Fu, Xiaorong, Miao, Ren, Pewa, Alvin D., Brown, Kathryn S., Lane, Erin E., Dohlman, Ashley, Zepeda-Orozco, Diana, Xie, Jianxin, Rutter, Jared, Norris, Andrew W., Cox, James E., Burgess, Shawn C., Potthoff, Matthew J., Taylor, Eric B.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754674/
https://ncbi.nlm.nih.gov/pubmed/26344103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.07.027
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