Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial Pyruvate Carrier (MPC) in mice attenuates NAFLD. Thus, we considered whether liver MPC disruption also prevents HCC. Here, we use the N-nitrosod...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746334/
https://ncbi.nlm.nih.gov/pubmed/31484072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.098
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