The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

OBJECTIVE: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gating pyruvate-driven gluconeogen...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681281/
https://ncbi.nlm.nih.gov/pubmed/29107293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.09.002
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