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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity
OBJECTIVE: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gating pyruvate-driven gluconeogen...
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| 出版年: | Mol Metab |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5681281/ https://ncbi.nlm.nih.gov/pubmed/29107293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.09.002 |
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