Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting Mpc1, an obligate M...

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Publicado en:Cell Rep
Main Authors: Ramstead, Andrew G., Wallace, Jared A., Lee, Soh-Hyun, Bauer, Kaylyn M., Tang, William W., Ekiz, H. Atakan, Lane, Thomas E., Cluntun, Ahmad A., Bettini, Matthew L., Round, June L., Rutter, Jared, O’Connell, Ryan M.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170217/
https://ncbi.nlm.nih.gov/pubmed/32130894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.042
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