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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate

Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ(1)-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of interest. Here we show that the proline ana...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Campbell, Ashley C., Becker, Donald F., Gates, Kent S., Tanner, John J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166166/
https://ncbi.nlm.nih.gov/pubmed/32159324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00935
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