Evidence for Hysteretic Substrate Channeling in the Proline Dehydrogenase and Δ(1)-Pyrroline-5-carboxylate Dehydrogenase Coupled Reaction of Proline Utilization A (PutA)

PutA (proline utilization A) is a large bifunctional flavoenzyme with proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains that catalyze the oxidation of l-proline to l-glutamate in two successive reactions. In the PRODH active site, proline undergoes a two-el...

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Detalhes bibliográficos
Main Authors: Moxley, Michael A., Sanyal, Nikhilesh, Krishnan, Navasona, Tanner, John J., Becker, Donald F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916563/
https://ncbi.nlm.nih.gov/pubmed/24352662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523704
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