Structural Studies of Yeast Δ(1)-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State

[Image: see text] The proline catabolic enzyme Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the NAD(+)-dependent oxidation of γ-glutamate semialdehyde to l-glutamate. In Saccharomyces cerevisiae, ALDH4A1 is encoded by the PUT2 gene and known as Put2p. Here we report the steady-stat...

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Main Authors: Pemberton, Travis A., Srivastava, Dhiraj, Sanyal, Nikhilesh, Henzl, Michael T., Becker, Donald F., Tanner, John J.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954644/
https://ncbi.nlm.nih.gov/pubmed/24502590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500048b
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