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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate
Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ(1)-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of interest. Here we show that the proline ana...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7166166/ https://ncbi.nlm.nih.gov/pubmed/32159324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00935 |
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