Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization

A vaccine to prevent maternal acquisition of human cytomegalovirus (HCMV) during pregnancy is a primary strategy to reduce the incidence of congenital disease. The MF59-adjuvanted glycoprotein B (gB) protein subunit vaccine (gB/MF59) is the most efficacious vaccine tested to date for this indication...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nelson, Cody S., Jenks, Jennifer A., Pardi, Norbert, Goodwin, Matthew, Roark, Hunter, Edwards, Whitney, McLellan, Jason S., Pollara, Justin, Weissman, Drew, Permar, Sallie R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163130/
https://ncbi.nlm.nih.gov/pubmed/32051265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00186-20
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