2651. Protection Against Human Cytomegalovirus Acquisition Is Associated with IgG Binding to Cell-Associated CMV glycoprotein B in Two Historical gB/MF59 Vaccine Cohorts

BACKGROUND: Human cytomegalovirus (CMV) is the most common congenital infection worldwide. A CMV glycoprotein B (gB) subunit vaccine with MF59 adjuvant achieved ~50% protection in phase II clinical trials in postpartum and adolescent women. Interestingly, postpartum vaccinees showed poor virus neutr...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Jenks, Jennifer A, Nelson, Cody S, Pass, Robert F, Bernstein, David I, Roark, Hunter K, Chan, Cliburn, Permar, Sallie R
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810453/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2329
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