2772. HCMV gB Ectodomain Subunit and gB mRNA Vaccines Reduce AD-3 Immunodominance and Elicit More Durable Antibody Responses Than gB/MF59 Immunization

BACKGROUND: A vaccine to prevent maternal acquisition of human cytomegalovirus (HCMV) during pregnancy is one potential strategy to reduce the incidence of congenital disease. The MF59-adjuvanted glycoprotein B (gB/MF59) protein subunit vaccine is the most efficacious tested to-date, though achieved...

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Veröffentlicht in:Open Forum Infect Dis
Hauptverfasser: Nelson, Cody S, Jenks, Jennifer A, Pardi, Norbert, Roark, Hunter K, Goodwin, Matthew, Weissman, Drew, Permar, Sallie R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810577/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2449
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