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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...
Uloženo v:
| Vydáno v: | Acta Pharm Sin B |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7161709/ https://ncbi.nlm.nih.gov/pubmed/32322466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.08.008 |
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