Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Zhang, Baoyuan, Lyu, Junfang, Yang, Eun Ju, Liu, Yifan, Wu, Changjie, Pardeshi, Lakhansing, Tan, Kaeling, Chen, Qiang, Xu, Xiaoling, Deng, Chu-Xia, Shim, Joong Sup
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161709/
https://ncbi.nlm.nih.gov/pubmed/32322466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.08.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados